Phospho-BCL2 (Ser70) Rekombinanter Antikörper
Phospho-BCL2 (Ser70) Rekombinant Antikörper für WB, IHC, FC (Intra), Indirect ELISA
Wirt / Isotyp
Kaninchen / IgG
Getestete Reaktivität
human
Anwendung
WB, IHC, FC (Intra), Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
230061A8
Kat-Nr. : 80771-2-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
80771-2-PBS bindet in WB, IHC, FC (Intra), Indirect ELISA Phospho-BCL2 (Ser70) und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Kaninchen / IgG |
Klonalität | Rekombinant |
Typ | Antikörper |
Immunogen | Peptid |
Vollständiger Name | B-cell CLL/lymphoma 2 |
Berechnetes Molekulargewicht | 26 kDa |
Beobachtetes Molekulargewicht | 26 kDa |
GenBank-Zugangsnummer | BC027258 |
Gene symbol | BCL2 |
Gene ID (NCBI) | 596 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-A-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
BCL2 belongs to the Bcl-2 family. The anti-apoptotic protein BCL2 can bind to the pro-apoptotic protein BAX or BAK1 to form heterodimers that modulate apoptosis. BCL2 phosphorylation at Ser70 enhances binding to BAX and BAD and is essential for its anti-apoptotic activity. Conversely, BCL2 also regulates autophagy via interaction with BECN1/Beclin 1; moreover, BCL2 phosphorylation including at Ser70 leads to its dissociation from BECN1 and induction of autophagy. These findings suggest that BCL2 regulates the balance between apoptosis and autophagy. (PMID: 29433359)