Phospho-BCL2 (Ser70) Rekombinanter Antikörper

Phospho-BCL2 (Ser70) Rekombinant Antikörper für WB, IHC, FC (Intra), Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, FC (Intra), Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

230061A8

Kat-Nr. : 80771-2-PBS

Synonyme

BCL-2, BCL2, 230061A8



Geprüfte Anwendungen

Produktinformation

80771-2-PBS bindet in WB, IHC, FC (Intra), Indirect ELISA Phospho-BCL2 (Ser70) und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name B-cell CLL/lymphoma 2
Berechnetes Molekulargewicht 26 kDa
Beobachtetes Molekulargewicht26 kDa
GenBank-ZugangsnummerBC027258
Gene symbol BCL2
Gene ID (NCBI) 596
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

BCL2 belongs to the Bcl-2 family. The anti-apoptotic protein BCL2 can bind to the pro-apoptotic protein BAX or BAK1 to form heterodimers that modulate apoptosis. BCL2 phosphorylation at Ser70 enhances binding to BAX and BAD and is essential for its anti-apoptotic activity. Conversely, BCL2 also regulates autophagy via interaction with BECN1/Beclin 1; moreover, BCL2 phosphorylation including at Ser70 leads to its dissociation from BECN1 and induction of autophagy. These findings suggest that BCL2 regulates the balance between apoptosis and autophagy. (PMID: 29433359)