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Phospho-TrkA (Tyr496)/TrkB (Tyr516) Rekombinanter Antikörper

Phospho-TrkA (Tyr496)/TrkB (Tyr516) Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

241917B1

Kat-Nr. : 84976-1-PBS

Synonyme

NTRK1, Trk A, TRK, p140 TrkA, MTC

Filter:
  • Western Blot (WB) analysis of various lysates using Phospho-TrkA (Tyr496)/TrkB (Tyr516) Recombinant an (84976-1-RR)

    WB analysis using 84976-1-RR (same clone as 84976-1-PBS)

    Non-treated and pervanadate treated HeLa cells were subjected to SDS PAGE followed by western blot with 84976-1-RR (Phospho-NTRK1 (Tyr496) antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Vinculin (66305-1-Ig) antibody as a loading control. This data was developed using the same antibody clone with 84976-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84976-1-PBS bindet in WB, Indirect ELISA Phospho-TrkA (Tyr496)/TrkB (Tyr516) und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name neurotrophic tyrosine kinase, receptor, type 1
Beobachtetes Molekulargewicht140 kDa
GenBank-ZugangsnummerBC062580
Gene symbol NTRK1
Gene ID (NCBI) 4914
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

The tyrosine kinase receptor TrkA (or neurotrophin receptor kinase 1, NTRK1) has been predominately studied for its role during the development of the nervous system. In developing neurons, TrkA activation upon binding of its ligands nerve growth factor (NGF) or neurotrophin-3 (NT-3) results in the stimulation of various tyrosine kinase-induced signaling pathways leading to neuronal outgrowth. (PMID: 32957504) This antibody recognizes the phosphorylation of TrkA at site 496, which is the phosphorylation of the TrkA-I(isoform 2) sequence at site 490.