Phospho-P53 (Ser46) Monoklonaler Antikörper
Phospho-P53 (Ser46) Monoklonal Antikörper für WB, IHC, IF/ICC, FC (Intra), Cytometric bead array, Indirect ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human
Anwendung
WB, IHC, IF/ICC, FC (Intra), Cytometric bead array, Indirect ELISA
Konjugation
Unkonjugiert
CloneNo.
1D10A12
Kat-Nr. : 67900-1-PBS
Synonyme
Geprüfte Anwendungen
Produktinformation
67900-1-PBS bindet in WB, IHC, IF/ICC, FC (Intra), Cytometric bead array, Indirect ELISA Phospho-P53 (Ser46) und zeigt Reaktivität mit human
Getestete Reaktivität | human |
Wirt / Isotyp | Maus / IgG1 |
Klonalität | Monoklonal |
Typ | Antikörper |
Immunogen | Peptid |
Vollständiger Name | tumor protein p53 |
Berechnetes Molekulargewicht | 44 kDa |
Beobachtetes Molekulargewicht | 53 kDa |
GenBank-Zugangsnummer | BC003596 |
Gene symbol | P53 |
Gene ID (NCBI) | 7157 |
Konjugation | Unkonjugiert |
Form | Liquid |
Reinigungsmethode | Protein-G-Reinigung |
Lagerungspuffer | PBS only |
Lagerungsbedingungen | Store at -80°C. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
P53 is activated in response to alteration of normal cell homeostasis, including DNA damage, nutrient starvation, heat shock, virus infection, pH change, hypoxia, and oncogene activation. P53 maintains genetic stability by regulating different processes, such as cell-cycle arrest, DNA synthesis and repair, programmed cell death, and energy metabolism. In non-stressed conditions these proteins bind p53, ubiquitylate it and target it for degradation by the proteasome. In stressed conditions the function of the MdM2-MdM4 complex is blocked by phosphorylation, protein-binding events and/or enhanced degradation. (PMID: 19935675, PMID: 24379683)