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Phospho-PLCG2 (Tyr1217) Rekombinanter Antikörper

Phospho-PLCG2 (Tyr1217) Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

240631F2

Kat-Nr. : 84456-1-PBS

Synonyme

PLCG2, Phospholipase C IV, Phospholipase C gamma 2, Phosphoinositide phospholipase C-gamma-2, EC:3.1.4.11

Filter:
  • Western Blot (WB) analysis of various lysates using Phospho-PLCG2 (Tyr1217) Recombinant antibody (84456-1-RR)

    WB analysis using 84456-1-RR (same clone as 84456-1-PBS)

    Non-treated and pervanadate treated Ramos cells were subjected to SDS PAGE followed by western blot with 84456-1-RR (Phospho-PLCG2 (Tyr1217) antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Lamin B1 (66095-1-Ig) antibody as a loading control. This data was developed using the same antibody clone with 84456-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84456-1-PBS bindet in WB, Indirect ELISA Phospho-PLCG2 (Tyr1217) und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name phospholipase C, gamma 2 (phosphatidylinositol-specific)
Berechnetes Molekulargewicht 148 kDa
Beobachtetes Molekulargewicht150 kDa
GenBank-ZugangsnummerBC007565
Gene symbol PLCG2
Gene ID (NCBI) 5336
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein A purfication
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Phospholipase C gamma 2 (PLCG2) belongs to the family of phospholipase C-gamma, which is the downstream molecule of the CSF1R. Previous studies have demonstrated that PLCG2 was required for CSF1-induced differentiation of monocytes, microglia, immune, inflammatory responses. PLCG2 phosphorylation leads to an increase in production of the cellular signaling molecules, diacylglycerol (DAG), and inositol 1,4,5 trisphosphate (IP3), which further promotes a wide range of downstream signals, including the phosphorylation of protein kinase C (PKC) family members, such as PKC epsilon (PKCε). (PMID: 32522286)