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Phospho-STAT6 (Tyr641) Rekombinanter Antikörper

Phospho-STAT6 (Tyr641) Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250940C12

Kat-Nr. : 86641-1-PBS

Synonyme

p STAT6 (Tyr641), Phospho STAT6, Phospho STAT6 (Tyr641), Phospho STAT6(Tyr641), Phospho-STAT6

Filter:
  • Western Blot (WB) analysis of various lysates using Phospho-STAT6 (Tyr641) Recombinant monoclonal anti (86641-1-RR)

    WB analysis using 86641-1-RR (same clone as 86641-1-PBS)

    Non-treated ACHN cells and IL-4 treated ACHN cells were subjected to SDS PAGE followed by western blot with 86641-1-RR (Phospho-STAT6 (Tyr641) antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and re-blotted with Vinculin (66305-1-Ig) antibody as a loading control. This data was developed using the same antibody clone with 86641-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86641-1-PBS bindet in WB, Indirect ELISA Phospho-STAT6 (Tyr641) und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name signal transducer and activator of transcription 6, interleukin-4 induced
Berechnetes Molekulargewicht 100 kDa
Beobachtetes Molekulargewicht110 kDa
GenBank-ZugangsnummerBC005823
Gene symbol STAT6
Gene ID (NCBI) 6778
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

STAT6, also named as Signal transducer and activator of transcription 6, is a 847 amino acid protein, which belongs to the transcription factor STAT family. p-STAT6(Tyr641) is a biomarker of Th2-high inflammation, targeted by IL-4Rα blockers (dupilumab) and JAK1/3 inhibitors. High p-STAT6 in TAMs correlates with M2 polarization and radioresistance, blocking IL-4 or JAK1/3 decreases Tyr641 phosphorylation and restores anti-tumor immunity. (PMID: 37474750)