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Podoplanin Rekombinanter Antikörper

Podoplanin Rekombinant Antikörper für FC

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus

Anwendung

FC

Konjugation

Unkonjugiert

CloneNo.

250618A2

Kat-Nr. : 98492-3-PBS

Synonyme

E11, Glycoprotein 38, Gp38, Ots8, OTS-8

Filter:
  • Flow cytometry (FC) experiment of C2C12 cells using Anti-Mouse Podoplanin Rabbit Recombinant Antibody (98492-3-RR)

    FC experiment of C2C12 using 98492-3-RR (same clone as 98492-3-PBS)

    1x10^6 C2C12 cells were surface stained with 0.25 ug Anti-Mouse Podoplanin Rabbit RecAb (98492-3-RR, Clone: 250618A2) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98492-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

98492-3-PBS bindet in FC Podoplanin und zeigt Reaktivität mit Maus

Getestete Reaktivität Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Podoplanin fusion protein Eg2861
Vollständiger Name podoplanin
Berechnetes Molekulargewicht18 kDa
GenBank-ZugangsnummerNM_010329.3
Gene symbol Pdpn
Gene ID (NCBI) 14726
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C.

Hintergrundinformationen

Podoplanin was identified as a glycoprotein found in the cell membranes of glomerular epithelial cells (podocyte) (PMID: 9327748). It is a lymphatic marker because the expression of podoplanin has been detected in lymphatic but not blood vascular endothelium, and is useful as the marker of tumor-associated Lymphangiogenesis. Podoplanin has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells. It may be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, Podoplanin induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. It is required for normal lung cell proliferation and alveolus formation at birth. Podoplanin induces platelet aggregation. It does not have any effect on folic acid or amino acid transport and does not function as a water channel or as a regulator of aquaporin-type water channels.