• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Presenilin-1-Specific Rekombinanter Antikörper

Presenilin-1-Specific Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Affe, human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250834G3

Kat-Nr. : 83618-5-PBS

Synonyme

Presenilin-1, PSEN1, AD3, presenilin 1, Presenilin1

Filter:
  • Western Blot (WB) analysis of various lysates using Presenilin-1-Specific Recombinant antibody (83618-5-RR)

    WB analysis using 83618-5-RR (same clone as 83618-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 83618-5-RR (PSEN1-S310 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83618-5-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

83618-5-PBS bindet in WB, Indirect ELISA Presenilin-1-Specific und zeigt Reaktivität mit Affe, human, Maus, Ratten

Getestete Reaktivität Affe, human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name presenilin 1
Berechnetes Molekulargewicht 467 aa, 53 kDa
Beobachtetes Molekulargewicht21 kDa, 53 kDa
GenBank-ZugangsnummerBC011729
Gene symbol PSEN1
Gene ID (NCBI) 5663
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome (PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein.