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Prion protein PrP/CD230 Rekombinanter Antikörper

Prion protein PrP/CD230 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243104D11

Kat-Nr. : 85611-4-PBS

Synonyme

Prion protein PrP, PRNP, PrP, Alternative prion protein, AltPrP

Filter:
  • Western Blot (WB) analysis of fetal human brain tissue using Prion protein PrP/CD230 Recombinant antibody (85611-4-RR)

    WB analysis of fetal human brain using 85611-4-RR (same clone as 85611-4-PBS)

    fetal human brain tissue was subjected to SDS PAGE followed by western blot with 85611-4-RR (PRNP antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85611-4-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

85611-4-PBS bindet in WB, Indirect ELISA Prion protein PrP/CD230 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Prion protein PrP/CD230 fusion protein Eg3359
Vollständiger Name prion protein
Beobachtetes Molekulargewicht 20-35 kDa
GenBank-ZugangsnummerBC012844
Gene symbol PrP
Gene ID (NCBI) 5621
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Prion protein (PRNP) is a ubiquitous membrane glycoprotein whose abnormal self-replicating, misfolded form is widely believed to cause several central nervous system disorders, collectively known as Transmissible Spongiform Encephalopathies (TSE). Prion diseases are TSEs, attributed to conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer that accumulates in the brain. The two isoforms, PrPC and PrPS, have the same primary amino acid sequence and only differ in conformation. While PrPC is composed of 42% α-helix and only 3% β-sheet, PrPSc is composed of 30% α-helix and 43% β-sheet. PrPC converts to its pathogenic isoform when the region corresponding to the residues 108-144 fold into β-sheets. PrPC is very soluble in detergents and easily digested by proteases while the PrPSc is insoluble in detergents and resistant to protease digestion. Prion diseases exist in infectious, sporadic, and genetic forms.