Protein Z Monoklonaler Antikörper

Protein Z Monoklonal Antikörper für WB, ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

WB, ELISA

Konjugation

Unkonjugiert

CloneNo.

2A1D3

Kat-Nr. : 68394-1-Ig

Synonyme

PROZ, PZ, Vitamin K dependent protein Z

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  WB analysis using 68394-1-Ig

  Various lysates were subjected to SDS PAGE followed by western blot with 68394-1-Ig (Protein Z antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: human plasma

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Produktinformation

68394-1-Ig bindet in WB, ELISA Protein Z und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: Protein Z fusion protein Ag13051
• Vollständiger Name: protein Z, vitamin K-dependent plasma glycoprotein
• Berechnetes Molekulargewicht: 400 aa, 45 kDa
• Beobachtetes Molekulargewicht: 45-47 kDa, 27 kDa
• GenBank-Zugangsnummer: BC074906
• Gene symbol: PROZ
• Gene ID (NCBI): 8858
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Protein Z (PZ, PROZ) is a vitamin K-dependent plasma protein that serves as a cofactor for activated factor X inhibition by the PZ-dependent protease inhibitor (PMID: 16938126). Reduced circulating levels of PZ have been suggested to play a role in the occurrence of bleeding (PMID: 7495103) and deep vein thrombosis (DVT) (PMID: 10829076), as well as in unexplained abortions with early fetal loss (PMID: 11895801), late fetal demise and intrauterine growth restriction (PMID: 16260213), acute coronary syndromes (PMID: 14652653), and stroke (PMID: 11570404). In addition, PZ may be a biomarker for the early diagnosis of pancreatic cancer (PMID: 31025496). It has two isoforms with molecular weights of 44 kDa and 47 kDa.