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Protein Z Monoklonaler Antikörper

Protein Z Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2A1D3

Kat-Nr. : 68394-1-PBS

Synonyme

PROZ, PZ, Vitamin K dependent protein Z

Filter:
  • Western Blot (WB) analysis of various lysates using Protein Z Monoclonal antibody (68394-1-Ig)

    WB analysis using 68394-1-Ig (same clone as 68394-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68394-1-Ig (Protein Z antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68394-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68394-1-PBS bindet in WB, Indirect ELISA Protein Z und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen Protein Z fusion protein Ag13051
Vollständiger Name protein Z, vitamin K-dependent plasma glycoprotein
Berechnetes Molekulargewicht 400 aa, 45 kDa
Beobachtetes Molekulargewicht 45-47 kDa, 27 kDa
GenBank-ZugangsnummerBC074906
Gene symbol PROZ
Gene ID (NCBI) 8858
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Protein Z (PZ, PROZ) is a vitamin K-dependent plasma protein that serves as a cofactor for activated factor X inhibition by the PZ-dependent protease inhibitor (PMID: 16938126). Reduced circulating levels of PZ have been suggested to play a role in the occurrence of bleeding (PMID: 7495103) and deep vein thrombosis (DVT) (PMID: 10829076), as well as in unexplained abortions with early fetal loss (PMID: 11895801), late fetal demise and intrauterine growth restriction (PMID: 16260213), acute coronary syndromes (PMID: 14652653), and stroke (PMID: 11570404). In addition, PZ may be a biomarker for the early diagnosis of pancreatic cancer (PMID: 31025496). It has two isoforms with molecular weights of 44 kDa and 47 kDa.