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RAMP2 Polyklonaler Antikörper

RAMP2 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13223-2-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of mouse brain tissue using RAMP2 Polyclonal antibody (13223-2-AP)

    WB analysis of mouse brain using 13223-2-AP (same clone as 13223-2-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 13223-2-AP (RAMP2 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13223-2-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using RAMP2 Polyclonal antibody (13223-2-AP)

    IHC staining of human breast cancer using 13223-2-AP (same clone as 13223-2-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer using 13223-2-AP (RAMP2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 13223-2-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

13223-2-PBS bindet in WB, IHC, Indirect ELISA RAMP2 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen RAMP2 fusion protein Ag4028
Vollständiger Name receptor (G protein-coupled) activity modifying protein 2
Berechnetes Molekulargewicht 175 aa, 20 kDa
Beobachtetes Molekulargewicht 20 kDa
GenBank-ZugangsnummerBC027975
Gene symbol RAMP2
Gene ID (NCBI) 10266
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RAMP2 (receptor-activity-modifying protein) is a member of the RAMP family of single-transmembrane-domain proteins which consist of an N-terminal extracellular domain, a transmembrane region and a short intracellular C-terminal tail. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a G protein-coupled receptor, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. RAMP1 transports the CRLR to the plasma membrane and then remains associated with it to function as a terminally glycosylated CGRP receptor, while RAMP2 and RAMP3 transfer the CRLR to the cell surface to generate receptors that are preferentially selective for adrenomedullin. (PMID: 9620797; 16188935)