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RAP1GAP Rekombinanter Antikörper

RAP1GAP Rekombinant Antikörper für IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250422B8

Kat-Nr. : 86011-1-PBS

Synonyme

KIAA0474, RAP1 GTPase activating protein, Rap1 GTPase-activating protein 1, RAP1GA1, RAP1GAP1

Filter:
  • Immunofluorescence (IF) / fluorescent staining of A549 cells using RAP1GAP Recombinant antibody (86011-1-RR)

    IF Staining of A549 using 86011-1-RR (same clone as 86011-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed A549 cells using RAP1GAP antibody (86011-1-RR, Clone: 250422B8 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 86011-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of Jurkat cells using RAP1GAP Recombinant antibody (86011-1-RR)

    IF Staining of Jurkat using 86011-1-RR (same clone as 86011-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using RAP1GAP antibody (86011-1-RR, Clone: 250422B8 ) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 86011-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86011-1-PBS bindet in IF/ICC, Indirect ELISA RAP1GAP und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen RAP1GAP fusion protein Ag5576
Vollständiger Name RAP1 GTPase activating protein
Berechnetes Molekulargewicht 73 kDa
GenBank-ZugangsnummerBC054490
Gene symbol RAP1GAP
Gene ID (NCBI) 5909
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Rap1 GTPase-activating protein (Rap1GAP) is an important tumor suppressor. Rap1GAP was associated with the AMPK and NF-κB signaling pathways and that Rap1GAP inhibited AMPK/SIRT1 and activated the NF-κB signaling pathway in model animals. Rap1GAP was verified to regulate the AMPK SIRT1/NF-κB signaling pathway and exacerbate the damage to myocardial cells caused by ischemia and hypoxia (PMID: 38320624). Rap1GAP is involved in Ang II-induced cardiomyocyte hypertrophy through the regulation of autophagy (PMID: 33936386). Rap1GAP, which is the GTPase-activating protein of Rap1, can bind to Rap1, promote the transformation of GTP from its active to inactive form, and terminate signal transduction (PMID: 21295042).