• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0
  • Featured Product
  • KD/KO Validated

RBBP8 Polyklonaler Antikörper

RBBP8 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12624-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of Raji cells using RBBP8 Polyclonal antibody (12624-1-AP)

    WB analysis of Raji using 12624-1-AP (same clone as 12624-1-PBS)

    Raji cells were subjected to SDS PAGE followed by western blot with 12624-1-AP (RBBP8 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12624-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A431 cells using RBBP8 Polyclonal antibody (12624-1-AP)

    WB analysis of A431 using 12624-1-AP (same clone as 12624-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 12624-1-AP (RBBP8 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12624-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

12624-1-PBS bindet in WB, Indirect ELISA RBBP8 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen RBBP8 fusion protein Ag3314
Vollständiger Name retinoblastoma binding protein 8
Berechnetes Molekulargewicht 103 kDa
Beobachtetes Molekulargewicht 120 kDa
GenBank-ZugangsnummerBC030590
Gene symbol RBBP8
Gene ID (NCBI) 5932
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RBBP8 is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. It functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. It interacted with BRCA1 to form a complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Also it promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations