- Featured Product
- KD/KO Validated
RBBP9 Monoklonaler Antikörper
RBBP9 Monoklonal Antikörper für
Wirt / Isotyp
Maus / IgG2b
Getestete Reaktivität
human
Anwendung
Konjugation
CoraLite®594 Fluorescent Dye
CloneNo.
3D5E11
Kat-Nr. : CL594-66015
Synonyme
Geprüfte Anwendungen
Produktinformation
CL594-66015 bindet in RBBP9 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Maus / IgG2b |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | RBBP9 fusion protein Ag17864 |
| Vollständiger Name | retinoblastoma binding protein 9 |
| Berechnetes Molekulargewicht | 186 aa, 21 kDa |
| Beobachtetes Molekulargewicht | 22 kDa |
| GenBank-Zugangsnummer | BC015938 |
| Gene symbol | RBBP9 |
| Gene ID (NCBI) | 10741 |
| Konjugation | CoraLite®594 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 588 nm / 604 nm |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
| Lagerungsbedingungen | Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
RBBP9, also named as BOG, RBBP10, RBBP-9, RBBP-10 and Protein BOG, belongs to the RBBP9 family. It may play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-β1 through interaction with retinoblastoma and the subsequent displacement of E2F-1. RBBP9 is a tumor-associated serine hydrolase activity required for pancreatic neoplasia. It mediates suppression of TGF-β signaling is required for E-cadherin expression as loss of the serine hydrolase activity leads to a reduction in E-cadherin levels and a concomitant decrease in the integrity of tumor cell-cell junctions..RBBP9 protein levels were equivalent in paired primary tumor and nonneoplastic specimens(PMID:20080647)
