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RBM15 Monoklonaler Antikörper

RBM15 Monoklonal Antikörper für

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human

Anwendung

Konjugation

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

4A1A4

Kat-Nr. : CL488-66059

Synonyme

FLJ12479, FLJ21943, One twenty two protein 1, OTT, OTT1, RBM15, RNA binding motif protein 15, SPEN

Geprüfte Anwendungen

Produktinformation

CL488-66059 bindet in RBM15 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Maus / IgG2a
Klonalität Monoklonal
Typ Antikörper
Immunogen RBM15 fusion protein Ag17970
Vollständiger Name RNA binding motif protein 15
Berechnetes Molekulargewicht 105 kDa
Beobachtetes Molekulargewicht 107 kDa
GenBank-ZugangsnummerBC006397
Gene symbol RBM15
Gene ID (NCBI) 64783
Konjugation CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission maxima wavelengths493 nm / 522 nm
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA
LagerungsbedingungenBei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RNA-binding motif protein 15 (RBM15) belongs to the SPEN protein family, which have repressor function in several signaling pathway, and may bind to RNA through interaction with spliceosome components. It was first described as a 5′ translocation partner of the MAL gene in t(1,22)(p13;q13) infant acute megakaryocytic leukemia, and it functions in murine hematopoiesis through modulating Notch-induced transcriptional activation, which play crucial roles in leukemogenesis. Decreasing RBM15 levels with RNA interference could inhibit the growth and proliferation, block the cell cycle, and induce apoptosis in CML cells.