RENALASE Monoklonaler Antikörper

RENALASE Monoklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

3A12F5

Kat-Nr. : 60128-1-PBS

Synonyme

C10orf59, 3A12F5, Monoamine oxidase C, MAO-C, MAO C

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  WB analysis using 60128-1-Ig (same clone as 60128-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 60128-1-Ig (RENALASE antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 60128-1-Ig (same clone as 60128-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 60128-1-Ig (RENALASE antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

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  WB analysis of MG-63 using 60128-1-Ig (same clone as 60128-1-PBS)

  MG-63 cells were subjected to SDS PAGE followed by western blot with 60128-1-Ig (RENALASE antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 60128-1-Ig (same clone as 60128-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney slide using 60128-1-Ig (RENALASE Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

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  IHC staining of human kidney using 60128-1-Ig (same clone as 60128-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human kidney slide using 60128-1-Ig (RENALASE Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

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  IHC staining of human skeletal muscle using 60128-1-Ig (same clone as 60128-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human skeletal muscle slide using 60128-1-Ig (RENALASE Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

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  IHC staining of human skeletal muscle using 60128-1-Ig (same clone as 60128-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human skeletal muscle slide using 60128-1-Ig (RENALASE Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 60128-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

60128-1-PBS bindet in WB, IHC, Indirect ELISA RENALASE und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: RENALASE fusion protein Ag13061
• Vollständiger Name: chromosome 10 open reading frame 59
• Berechnetes Molekulargewicht: 38 kDa
• Beobachtetes Molekulargewicht: 38 kDa
• GenBank-Zugangsnummer: BC005364
• Gene symbol: RENALASE
• Gene ID (NCBI): 55328
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity. (PMID:15841207 ) This antibody is specific to RNLS.