Renin receptor,ATP6AP2 Monoklonaler Antikörper
Renin receptor,ATP6AP2 Monoklonal Antikörper für ELISA
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human
Anwendung
ELISA
Konjugation
Unkonjugiert
CloneNo.
5H2E8
Kat-Nr. : 60017-1-Ig
Synonyme
Galerie der Validierungsdaten
Geprüfte Anwendungen
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Produktinformation
60017-1-Ig bindet in ELISA Renin receptor,ATP6AP2 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | Renin receptor,ATP6AP2 fusion protein Ag1360 |
| Vollständiger Name | ATPase, H+ transporting, lysosomal accessory protein 2 |
| Berechnetes Molekulargewicht | 39 kDa |
| GenBank-Zugangsnummer | BC010395 |
| Gene symbol | ATP6AP2 |
| Gene ID (NCBI) | 10159 |
| Konjugation | Unkonjugiert |
| Form | Liquid |
| Reinigungsmethode | Protein-A-Reinigung |
| Lagerungspuffer | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. |
| Lagerungsbedingungen | Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
ATP6AP2, also named as ATP6IP2, CAPER, ELDF10, N14F, ATP6M8-9, Renin receptor and prorenin receptor, is believed to potentiate the renin-angiotensin system (RAS), conferring to prorenin, a likely pathological role at tissue level. The PRR has been identified in the microvascular endothelial cells of the retina, in which it seems to be involved in pathological neovascularization processes. The present study demonstrates for the first time that the PRR is expressed in human ATP6AP2 and suggests a molecular mechanism by which hypertension may exacerbate the pathology of dry AMD. ATP6AP2 functions as a renin and prorenin cellular receptor. It may mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Defects in ATP6AP2 are a cause of mental retardation X-linked with epilepsy (MRXE). (PMID:19580809)
