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RETSAT Polyklonaler Antikörper

RETSAT Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16895-1-PBS

Synonyme

All-trans-13,14-dihydroretinol saturase, All-trans-retinol 13,14-reductase, EC:1.3.99.23, PPAR-alpha-regulated and starvation-induced gene protein, PPSIG

Filter:
  • Western Blot (WB) analysis of various lysates using RETSAT Polyclonal antibody (16895-1-AP)

    WB analysis using 16895-1-AP (same clone as 16895-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 16895-1-AP (RETSAT antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16895-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

16895-1-PBS bindet in WB, Indirect ELISA RETSAT und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen RETSAT fusion protein Ag10420
Vollständiger Name retinol saturase (all-trans-retinol 13,14-reductase)
Berechnetes Molekulargewicht 610 aa, 69 kDa
Beobachtetes Molekulargewicht62-67 kDa
GenBank-ZugangsnummerBC011418
Gene symbol RETSAT
Gene ID (NCBI) 54884
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RETSAT (Retinol Saturase) is an enzyme-encoding gene that plays a critical role in cellular metabolism, primarily involved in the saturation of retinol (vitamin A) and other molecules. It catalyzes the conversion of all-trans-retinol to all-trans-13,14-dihydroretinol, a process that links vitamin A metabolism to lipid and glucose homeostasis. It is highly expressed in the liver, adipose tissue, and kidney and is regulated by the PPARγ master regulator of adipogenesis (PMID: 28855500; 38128827). RETSAT also has a role in cancer cell survival, particularly in hypoxic tumor environments, by enhancing resistance to replication stress (PMID: 36109793).