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REV1 Polyklonaler Antikörper

REV1 Polyklonal Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 17703-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using REV1 Polyclonal antibody (17703-1-AP)

    WB analysis using 17703-1-AP (same clone as 17703-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 17703-1-AP (REV1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17703-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of U2OS cells using REV1 Polyclonal antibody (17703-1-AP)

    IF Staining of U2OS using 17703-1-AP (same clone as 17703-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using REV1 antibody (17703-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-phalloidin (red). This data was developed using the same antibody clone with 17703-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

17703-1-PBS bindet in WB, IF/ICC, Indirect ELISA REV1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen REV1 fusion protein Ag11975
Vollständiger Name REV1 homolog (S. cerevisiae)
Berechnetes Molekulargewicht 1114 aa, 122 kDa
Beobachtetes Molekulargewicht140-150 kDa
GenBank-ZugangsnummerBC037734
Gene symbol REV1
Gene ID (NCBI) 51455
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Rev1 is a member of the TLS polymerase family and plays a key role in this mutagenic pathway, which allows the bypass of modified DNA bases and respectively, facilitates proliferation even in the presence of extensive DNA damage, such as during chemotherapy. Mutations in human REV1 have been detected in a minority of tumors, and single-nucleotide polymorphisms (SNPs) in the hREV1 gene have been linked to various types of human cancer.