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RHNO1 Polyklonaler Antikörper

RHNO1 Polyklonal Antikörper für IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

Konjugation

Unkonjugiert

Kat-Nr. : 27977-1-PBS

Synonyme

C12orf32, HKMT1188, HUS1, RAD1, RAD9

Filter:
  • Immunoprecipitation (IP) experiment of mouse thymus tissue using RHNO1 Polyclonal antibody (27977-1-AP)

    IP experiment of mouse thymus using 27977-1-AP (same clone as 27977-1-PBS)

    IP result of anti-RHNO1 (IP:27977-1-AP, 4ug; Detection:27977-1-AP 1:500) with mouse thymus tissue lysate 1320 ug. This data was developed using the same antibody clone with 27977-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

27977-1-PBS bindet in RHNO1 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen RHNO1 fusion protein Ag14789
Vollständiger Name chromosome 12 open reading frame 32
Berechnetes Molekulargewicht 238 aa, 27 kDa
Beobachtetes Molekulargewicht35 kDa
GenBank-ZugangsnummerBC005106
Gene symbol C12orf32
Gene ID (NCBI) 83695
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RHNO1 (Rad9-Hus1-Rad1 Interacting Nuclear Orphan 1) is a protein associated with the DNA replication stress (DRS) response and DNA repair. It interacts with the 9-1-1 checkpoint clamp and TopBP1 to activate the ATR/Chk1 signaling pathway, thereby maintaining genomic integrity. Additionally, RHNO1 has been identified as a key facilitator of theta-mediated end joining (TMEJ), a DNA repair mechanism related to cancer progression and chemotherapy resistance. In cancer research, RHNO1 is considered a potential therapeutic target due to its high expression in tumor cells and its regulatory role in cell proliferation and survival.