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RNASEH1 Monoklonaler Antikörper

RNASEH1 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2C8D3

Kat-Nr. : 68787-3-PBS

Synonyme

RNH1, RNASEH 1, RNase H1, EC:3.1.26.4, 2C8D3

Filter:
  • Western Blot (WB) analysis of various lysates using RNASEH1 Monoclonal antibody (68787-3-Ig)

    WB analysis using 68787-3-Ig (same clone as 68787-3-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68787-3-Ig (RNASEH1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68787-3-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using RNASEH1 Monoclonal antibody (68787-3-Ig)

    WB analysis using 68787-3-Ig (same clone as 68787-3-PBS)

    4T1 cells were subjected to SDS PAGE followed by western blot with 68787-3-Ig (RNASEH1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68787-3-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68787-3-PBS bindet in WB, Indirect ELISA RNASEH1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen RNASEH1 fusion protein Ag33948
Vollständiger Name ribonuclease H1
Berechnetes Molekulargewicht 32 kDa
Beobachtetes Molekulargewicht 32 kDa
GenBank-ZugangsnummerBC002973
Gene symbol RNASEH1
Gene ID (NCBI) 246243
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Ribonucleases H are enzymes that cleave the RNA of RNA/DNA hybrids that form during replication and repair and which could lead to DNA instability if they were not processed. Eukaryotic RNases H are larger and more complex than their prokaryotic counterparts [PMID:12667461]. Eukaryotic RNase H1 has acquired a Hybrid Binding Domain that confers processivity and affinity for the substrate. Because of its essential role and its similarities in structure and enzymatic mechanism to the RNase H of HIV reverse transcriptase, RNASEH1 has been implicated in mitochondrial DNA replication during mouse development [PMID:19228196].