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RNF123 Polyklonaler Antikörper

RNF123 Polyklonal Antikörper für WB, IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 25260-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using RNF123 Polyclonal antibody (25260-1-AP)

    WB analysis using 25260-1-AP (same clone as 25260-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 25260-1-AP (RNF123 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 25260-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of HeLa cells using RNF123 Polyclonal antibody (25260-1-AP)

    IP experiment of HeLa using 25260-1-AP (same clone as 25260-1-PBS)

    IP result of anti-RNF123 (IP:25260-1-AP, 4ug; Detection:25260-1-AP 1:600) with HeLa cells lysate 1200 ug. This data was developed using the same antibody clone with 25260-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

25260-1-PBS bindet in WB, IP, Indirect ELISA RNF123 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen RNF123 fusion protein Ag19653
Vollständiger Name ring finger protein 123
Berechnetes Molekulargewicht 1314 aa, 149 kDa
Beobachtetes Molekulargewicht149 kDa
GenBank-ZugangsnummerBC130632
Gene symbol RNF123
Gene ID (NCBI) 63891
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RING finger protein 123 (RNF123), also known as KPC1, is an E3 ubiquitin ligase that belongs to the RING-finger family of ligases that contain a 40-60-amino acid long RING domain which is essential for causing substrate ubiquitination (PMID: 29676528). RNF123 promoted TLR3/IRF7-induced type I IFN signaling and inhibited viral replication by degrading SOCS1 (PMID: 37014223).