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RNF220 Polyklonaler Antikörper

RNF220 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 32482-1-PBS

Synonyme

RING-type E3 ubiquitin transferase RNF220, RING finger protein 220, EC:2.3.2.27, E3 ubiquitin-protein ligase RNF220, C1orf164

Filter:
  • Western Blot (WB) analysis of various lysates using RNF220 Polyclonal antibody (32482-1-AP)

    WB analysis using 32482-1-AP (same clone as 32482-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32482-1-AP (RNF220 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32482-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

32482-1-PBS bindet in WB, Indirect ELISA RNF220 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen RNF220 fusion protein Ag36190
Vollständiger Name ring finger protein 220
Beobachtetes Molekulargewicht70 kDa
GenBank-ZugangsnummerBC034221
Gene symbol RNF220
Gene ID (NCBI) 55182
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RNF220 is an E3 ubiquitin ligase that plays a crucial role in the ubiquitination process, which targets proteins for degradation by the proteasome. Mutations in RNF220 have been linked to laminopathies, which are characterized by leukodystrophy, ataxia, and deafness. Additionally, RNF220 is involved in the progression of certain cancers, such as acute myeloid leukemia (AML) and colorectal cancer. Studies have shown that RNF220 promotes the proliferation of leukemia cells and reduces the degradation of Cyclin D1 protein through USP22. It also enhances canonical Wnt signaling through USP7-mediated deubiquitination of beta-catenin. (PMID: 32896826)