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RNF8 Monoklonaler Antikörper

RNF8 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

Hausschwein, human, Kaninchen, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

3G3H5

Kat-Nr. : 68521-1-PBS

Synonyme

FLJ12013, KIAA0646, ring finger protein 8, RNF8

Filter:
  • Western Blot (WB) analysis of various lysates using RNF8 Monoclonal antibody (68521-1-Ig)

    WB analysis using 68521-1-Ig (same clone as 68521-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68521-1-Ig (RNF8 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68521-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

68521-1-PBS bindet in WB, Indirect ELISA RNF8 und zeigt Reaktivität mit Hausschwein, human, Kaninchen, Maus, Ratten

Getestete Reaktivität Hausschwein, human, Kaninchen, Maus, Ratte
Wirt / Isotyp Maus / IgG1
Klonalität Monoklonal
Typ Antikörper
Immunogen RNF8 fusion protein Ag5292
Vollständiger Name ring finger protein 8
Berechnetes Molekulargewicht 485 aa, 56 kDa
Beobachtetes Molekulargewicht65-70 kDa
GenBank-ZugangsnummerBC007517
Gene symbol RNF8
Gene ID (NCBI) 9025
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-G-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RNF8, also named as KIAA0646 or E3 ubiquitin-protein ligase RNF8, is a 485 amino acid protein, which contains one RING-type zinc finger and one FHA domain. RNF8 localizes in the nucleus and belongs to the RNF8 family. E2-E3 ubiquitin ligase complex is composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.