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- KD/KO Validated
ROR1 Monoklonaler Antikörper
ROR1 Monoklonal Antikörper für
Wirt / Isotyp
Maus / IgG1
Getestete Reaktivität
human
Anwendung
Konjugation
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1F5D8
Kat-Nr. : CL488-66923
Synonyme
Geprüfte Anwendungen
Produktinformation
CL488-66923 bindet in ROR1 und zeigt Reaktivität mit human
| Getestete Reaktivität | human |
| Wirt / Isotyp | Maus / IgG1 |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | ROR1 fusion protein Ag14586 |
| Vollständiger Name | receptor tyrosine kinase-like orphan receptor 1 |
| Berechnetes Molekulargewicht | 937 aa, 104 kDa |
| Beobachtetes Molekulargewicht | 130 kDa |
| GenBank-Zugangsnummer | BC006374 |
| Gene symbol | ROR1 |
| Gene ID (NCBI) | 4919 |
| Konjugation | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Reinigungsmethode | Protein-G-Reinigung |
| Lagerungspuffer | PBS with 50% glycerol, 0.05% Proclin300, 0.5% BSA |
| Lagerungsbedingungen | Bei -20°C lagern. Vor Licht schützen. Nach dem Versand ein Jahr stabil. Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA. |
Hintergrundinformationen
ROR1 is a member of the RTK family of orphan receptors related to muscle specific kinase and Trk neurotrophin receptors (PMID: 18546292). ROR1 is primarily expressed by neural crest cells during embryogenesis. High expression of ROR1 is reported in many types of malignancies and is thought to be involved in tumor growth, apoptosis, and epithelial-mesenchymal transition (PMID: 26245996). The human ROR1 gene encodes a 937-amino acid protein with an Ig-like domain, a cysteine-rich domain, a kringle domain, a tyrosine kinase domain and a proline-rich domain. The calculated molecular weight of ROR1 is 104 kDa, but ROR1 has multiple N-glycosylation sites that generate post-translationally modified ROR1 at 130 kDa (PMID: 24752542).
