ROR2 Monoklonaler Antikörper

ROR2 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

1A12C5

Kat-Nr. : 67906-1-PBS

Synonyme

BDB, BDB1, NTRKR2, ROR2

---

• 

  WB analysis using 67906-1-Ig (same clone as 67906-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67906-1-Ig (ROR2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated Alpha Tubulin Monoclonal antibody (HRP-66031) as loading control. This data was developed using the same antibody clone with 67906-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 67906-1-Ig (same clone as 67906-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67906-1-Ig (ROR2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67906-1-PBS in a different storage buffer formulation.

• 

  WB analysis of NIH/3T3 using 67906-1-Ig (same clone as 67906-1-PBS)

  NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 67906-1-Ig (ROR2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67906-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

67906-1-PBS bindet in WB, Indirect ELISA ROR2 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: ROR2 fusion protein Ag31197
• Vollständiger Name: receptor tyrosine kinase-like orphan receptor 2
• Berechnetes Molekulargewicht: 943 aa, 105 kDa
• Beobachtetes Molekulargewicht: 105 kDa
• GenBank-Zugangsnummer: BC130522
• Gene symbol: ROR2
• Gene ID (NCBI): 4920
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Tyrosine-protein kinase transmembrane receptor ROR2 belongs to the ROR family of receptor tyrosine kinases (RTKs) (PMID: 12815588). ROR2 is a developmentally regulated protein that has significant expression and roles in a wide variety of tissues during early embryonic development. It was established that ROR2 plays a key role in skeletal and neural organogenesis, as well as in midgut development in the mouse, but then becomes repressed in adult tissues. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PMID: 25614331). Mutations in the ROR2 gene are associated with autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B (PMID: 12815588).