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RPRD2 Polyklonaler Antikörper

RPRD2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33037-1-PBS

Synonyme

HSPC099, KIAA0460, Regulation of nuclear pre-mRNA domain-containing protein 2

Filter:
  • Western Blot (WB) analysis of various lysates using RPRD2 Polyclonal antibody (33037-1-AP)

    WB analysis using 33037-1-AP (same clone as 33037-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33037-1-AP (RPRD2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33037-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

33037-1-PBS bindet in WB, Indirect ELISA RPRD2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen RPRD2 fusion protein Ag35410
Vollständiger Name regulation of nuclear pre-mRNA domain containing 2
Berechnetes Molekulargewicht155 kDa
Beobachtetes Molekulargewicht220 kDa
GenBank-ZugangsnummerBC045623
Gene symbol RPRD2
Gene ID (NCBI) 23248
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RPRD2 (or RNA-associated early-stage antiviral factor) has been shown to be upregulated upon T cell activation, is highly expressed in myeloid cells, binds viral reverse transcripts, and potently restricts HIV-1 infection. RPRD2 is also bound by HIV-1 Vpr and targeted for degradation by the proteasome upon reverse transcription, suggesting RPRD2 impedes reverse transcription and Vpr targeting overcomes this block. RPRD2 is mainly localized to the nucleus and binds RNA, DNA, and DNA:RNA hybrids. RPRD2 has been shown to negatively regulate genome-wide transcription and interact with the HUSH and PAF1 complexes which repress HIV transcription and are implicated in maintenance of HIV latency (PMID: 37882563).