RUNX3 Polyklonaler Antikörper

RUNX3 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, ELISA

Konjugation

Unkonjugiert

Publikationen(3)

Kat-Nr. : 27099-1-AP

Synonyme

AML2, CBF alpha 3, CBFA3, CBF-alpha-3, Core-binding factor subunit alpha-3

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  WB analysis using 27099-1-AP

  Jurkat cells were subjected to SDS PAGE followed by western blot with 27099-1-AP (RUNX3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Geprüfte Anwendungen

• Erfolgreiche Detektion in WB: Jurkat-Zellen

Empfohlene Verdünnung

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 2 publications below
• IHC: See 1 publications below

Produktinformation

27099-1-AP bindet in WB, IHC, ELISA RUNX3 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: RUNX3 fusion protein Ag24339
• Vollständiger Name: runt-related transcription factor 3
• Berechnetes Molekulargewicht: 44 kDa
• Beobachtetes Molekulargewicht: 45-55 kDa
• GenBank-Zugangsnummer: BC013362
• Gene symbol: RUNX3
• Gene ID (NCBI): 864
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

RUNX3, also known as AML2, CBFA3 and PEBP2A3, is a member of the RUNX family of transcription factors, which are crucial regulators of embryonic development and play key roles in various biological processes such as cell proliferation, apoptosis, differentiation and lineage commitment (PMID: 38430423). This protein functions as a tumour suppressor and is frequently deleted or transcriptionally silenced in various cancers, including gastric and colon cancer.

Publikationen

Species	Application	Title
human	WB	Mol Ther Nucleic Acids; Circular RNA circREPS2 Acts as a Sponge of miR-558 to Suppress Gastric Cancer Progression by Regulating RUNX3/β-catenin Signaling.; Authors - Xiong Guo
human	WB	Biochim Biophys Acta Mol Cell Res; Lemur tyrosine kinase 2 has a tumor-inhibition function in human glioblastoma by regulating the RUNX3/Notch pathway; Authors - Lei Zhang
	IHC	Biochim Biophys Acta Mol Basis Dis; A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast differentiation during early enamel formation; Authors - Jiayi Zhang