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SAMD4A Rekombinanter Antikörper

SAMD4A Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251369F11

Kat-Nr. : 86530-1-PBS

Synonyme

hSmaug1, KIAA1053, Protein Smaug homolog 1, SAM domain-containing protein 4A, SAMD4

Filter:
  • Western Blot (WB) analysis of various lysates using SAMD4A Recombinant antibody (86530-1-RR)

    WB analysis using 86530-1-RR (same clone as 86530-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86530-1-RR (SAMD4A antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86530-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 86530-1-RR

    Affinity and Kinetic Characterization of 86530-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86530-1-RR against Human SAMD4A were performed. The affinity constant is 2.33 nM.

Geprüfte Anwendungen

Produktinformation

86530-1-PBS bindet in WB, Indirect ELISA SAMD4A und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen SAMD4A fusion protein Ag11273
Vollständiger Name sterile alpha motif domain containing 4A
Berechnetes Molekulargewicht 529 aa, 59 kDa
Beobachtetes Molekulargewicht 70-71 kDa
GenBank-ZugangsnummerBC021726
Gene symbol SAMD4A
Gene ID (NCBI) 23034
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SAMD4A is also named as KIAA1053, SAMD4, SMAUG1, hSmaug1 and belongs to the SMAUG family. SAMD4A acts as a translational repressor of SRE-containing messengers. (PMID:16221671). In particular, as orthologous alternative splicing isoforms, mouse Samd4a E-form and human SAMD4A C-form containing the SAM domain were specific to testes. Samd4a/SAMD4A plays an essential role in normal spermatogenesis, and SAMD4A, as a spermatid specific marker, can be used for subcategorizing nonobstructive azoospermia patients (PMID:36274854). In mammalian cells, human SAMD4A can form a kind of mRNA‐silencing foci in the cytoplasm, acting differently from processing body and stress granules. Recently, it was reported that human SAMD4A can protect the host from viral infection by degrading viral RNA (PMID: 32341522). Indition, 14-3-3s negatively regulate the localization of the RNA-binding protein SAMD4A to cytoplasmic granules and inhibit its activity as a translational repressor (PMID: 36931259).