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SAMHD1 Rekombinanter Antikörper

SAMHD1 Rekombinant Antikörper für WB, IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

251815H5

Kat-Nr. : 86798-1-PBS

Synonyme

DCIP, Dendritic cell-derived IFNG-induced protein, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, dNTPase, EC:3.1.5.-

Filter:
  • Western Blot (WB) analysis of various lysates using SAMHD1 Recombinant monoclonal antibody (86798-1-RR)

    WB analysis using 86798-1-RR (same clone as 86798-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86798-1-RR (SAMHD1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86798-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using SAMHD1 Recombinant monoclonal antibody (86798-1-RR)

    IF Staining of HepG2 using 86798-1-RR (same clone as 86798-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using SAMHD1 antibody (86798-1-RR, Clone: 251815H5 ) at dilution of 1:1000 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 86798-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86798-1-PBS bindet in WB, IF/ICC, Indirect ELISA SAMHD1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen SAMHD1 fusion protein Ag3287
Vollständiger Name SAM domain and HD domain 1
Berechnetes Molekulargewicht 626 aa, 72 kDa
Beobachtetes Molekulargewicht 64-72 kDa
GenBank-ZugangsnummerBC036450
Gene symbol SAMHD1
Gene ID (NCBI) 25939
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SAMHD1, highly expressed by monocytes and monocyte-derived dendritic cells and by monocyte-derived macrophages at a lower extent, is reported as an HIV-1 restriction factor that inhibits the early step of the HIV-1 life cycle. Vpx (virus-like particles containing viral protein X) could overcome this block by interacting with SAMHD1, inducing proteasome-dependent degradation of SAMHD1. Mutations in SAMHD1 cause Aicardi-Goutières syndrome, a genetic encephalopathy with presumed immune pathogenesis. Three alternatively spliced transcripts encoding different isoforms have been described.