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SCAI Polyklonaler Antikörper

SCAI Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33449-1-PBS

Synonyme

C9orf126, Protein SCAI, Suppressor of cancer cell invasion protein

Filter:
  • Western Blot (WB) analysis of various lysates using SCAI Polyclonal antibody (33449-1-AP)

    WB analysis using 33449-1-AP (same clone as 33449-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33449-1-AP (SCAI antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33449-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

33449-1-PBS bindet in WB, Indirect ELISA SCAI und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SCAI fusion protein Ag38169
Vollständiger Name chromosome 9 open reading frame 126
Berechnetes Molekulargewicht70kDa，606aa
Beobachtetes Molekulargewicht60 kDa
GenBank-ZugangsnummerNM_001144877.2
Gene symbol C9orf126
Gene ID (NCBI) 286205
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SCAI (suppressor of cancer cell invasion) is a conserved protein that regulates invasive cell migration through three-dimensional matrices. SCAI acts on the RhoA-Dia1 signal transduction pathway and localizes in the nucleus, where it binds and inhibits the myocardin-related transcription factor MAL by forming a ternary complex with serum response factor (SRF). Genome-wide expression analysis surprisingly reveals that one of the strongest upregulated genes after suppression of SCAI is beta1-integrin. Decreased levels of SCAI are tightly correlated with increased invasive cell migration, and SCAI is downregulated in several human tumours. Functional analysis of the beta1-integrin gene strongly argues that SCAI is a novel transcriptional cofactor that controls gene expression downstream of Dia1 to dictate changes in cell invasive behaviour (PMID: 19350017).