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SCF Rekombinanter Antikörper

SCF Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250022H6

Kat-Nr. : 86214-1-PBS

Synonyme

Kitl, kit ligand

Filter:
  • Western Blot (WB) analysis of various lysates using SCF Recombinant antibody (86214-1-RR)

    WB analysis using 86214-1-RR (same clone as 86214-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86214-1-RR (SCF antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86214-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Recombinant protein using SCF Recombinant antibody (86214-1-RR)

    WB analysis of Recombinant protein using 86214-1-RR (same clone as 86214-1-PBS)

    Recombinant protein were subjected to SDS PAGE followed by western blot with 86214-1-RR (SCF antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86214-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86214-1-PBS bindet in WB, Indirect ELISA SCF und zeigt Reaktivität mit Maus, Ratten

Getestete Reaktivität Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen SCF fusion protein Eg0402
Vollständiger Name kit ligand
Berechnetes Molekulargewicht31KD
Beobachtetes Molekulargewicht 31 kDa
GenBank-ZugangsnummerNM_013598
Gene symbol Kitl
Gene ID (NCBI) 17311
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Stem cell factor (SCF) is also named as mast cell growth factor (MGF), Kit ligand (Kitl), c-Kit ligand, steel factor and Kitlg. SCF is a pleiotropic cytokine (also as a dimeric molecule) that mediates regulatory effects on inflammation, tissue remodeling, and fibrosis through binding to and activating its receptor tyrosine kinase c-Kit (PMID: 1698553, PMID: 8630386, PMID: 23073628). SCF is the ligand of c-Kit, a member of the RTKs family. Molecular activity of RTKs is a primary stimulus of cell motility, and expression of the SCF/c-Kit axis is associated with cell migration (PMID: 28629522). SCF is a cytokine that synergizes the effects of Epo during erythropoiesis. Stem cell factor plays a well-described role in regulating the survival, proliferation, migration, and differentiation of hematopoietic progenitors, melanocytes, and germ cells (PMID: 36688460). More recent studies have demonstrated SCF expression in dermal and intestinal epithelial cells, and increased SCF expression has been reported in the inflamed mucosa of individuals with IBD and colonitis (PMID: 18200049, PMID: 30157426).