SCN11A Rekombinanter Antikörper

SCN11A Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250003E1

Kat-Nr. : 85740-1-PBS

Synonyme

hNaN, NaN, NAV1.9, PN5, SCN12A

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  WB analysis using 85740-1-RR (same clone as 85740-1-PBS)

  rat brain tissue were subjected to SDS PAGE followed by western blot with 85740-1-RR (SCN11A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85740-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

85740-1-PBS bindet in WB, Indirect ELISA SCN11A und zeigt Reaktivität mit human, Ratten

• Getestete Reaktivität: human, Ratte
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: sodium channel, voltage-gated, type XI, alpha subunit
• Berechnetes Molekulargewicht: 205 kDa
• Beobachtetes Molekulargewicht: 205 kDa
• GenBank-Zugangsnummer: NM_001349253
• Gene symbol: SCN11A
• Gene ID (NCBI): 11280
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Sodium channel protein type 11 subunit alpha (SCN11A, also known as Nav1.9) is crucial for generating action potentials and regulating neuronal excitability, particularly in nociceptive neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (PMID: 33752606). Nav1.9 channels are involved in the formation of pain-sensing and have been implicated in peripheral inflammatory pain hypersensitivity. Additionally, SCN11A-mediated channels play a role in regulating colonic motility and neurotransmitter release in the enteric nervous system (PMID: 35711274).