SCN4A Rekombinanter Antikörper

SCN4A Rekombinant Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

243036A8

Kat-Nr. : 85698-1-PBS

Synonyme

HYKPP, HYPP, Na(V)1.4, NAC1A, Nav1.4

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  WB analysis using 85698-1-RR (same clone as 85698-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85698-1-RR (SCN4A antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85698-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skeletal muscle using 85698-1-RR (same clone as 85698-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 85698-1-RR (SCN4A antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85698-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse skeletal muscle using 85698-1-RR (same clone as 85698-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 85698-1-RR (SCN4A antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85698-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

85698-1-PBS bindet in WB, IHC, Indirect ELISA SCN4A und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Rekombinant
• Typ: Antikörper
• Immunogen: Peptid
• Vollständiger Name: sodium channel, voltage-gated, type IV, alpha subunit
• Berechnetes Molekulargewicht: 208 kDa
• Beobachtetes Molekulargewicht: 208 kDa
• GenBank-Zugangsnummer: NM_000334
• Gene symbol: SCN4A
• Gene ID (NCBI): 6329
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Sodium channel protein type 4 subunit alpha (SCN4A, also known as Nav1.4) is the pore-forming subunit of the primary sodium channel present in skeletal muscles (PMID: 16193245). Nav1.4 related channelopathies that affect skeletal muscle excitability are dominant diseases classified in two opposite groups as defined by the prevalent clinical symptoms: muscle stiffness and hypertonia (myotonia) episodes [non dystrophic myotonias (NDM)], and muscle weakness resulting in paralysis episodes (periodic paralyses; PP) (PMID: 20237798; 26285000).