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SCNN1A Polyklonaler Antikörper

SCNN1A Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 28707-1-PBS

Synonyme

ENaCa, Amiloride-sensitive sodium channel subunit alpha, Alpha-NaCH, Alpha-ENaC, Alpha NaCH

Filter:
  • Western Blot (WB) analysis of various lysates using SCNN1A Polyclonal antibody (28707-1-AP)

    WB analysis using 28707-1-AP (same clone as 28707-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 28707-1-AP (SCNN1A antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28707-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

28707-1-PBS bindet in WB, Indirect ELISA SCNN1A und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SCNN1A fusion protein Ag30063
Vollständiger Name sodium channel, nonvoltage-gated 1 alpha
Berechnetes Molekulargewicht 76 kDa
Beobachtetes Molekulargewicht60-70 kDa
GenBank-ZugangsnummerBC006526
Gene symbol SCNN1A
Gene ID (NCBI) 6337
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Amiloride-sensitive sodium channel subunit alpha (SCNN1A, also known as Alpha-ENaC and ENaCA) is essential for maintaining sodium homeostasis and is particularly important in the distal nephron and late distal convoluted tubule of the kidney, where aldosterone triggers ENaC activity (PMID: 18086683; 31654198). The ~97 kDa and ~75kDa bands represent the glycosylated and unglycosylated forms of SCNN1A (PMID: 19462466). It also migrated as intact (≈ 75 kDa) and furin-cleaved (≈ 50 kDa) in urinary extracellular vesicles (uEVs) (PMID: 31654198).