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SERPINB2 Polyklonaler Antikörper

SERPINB2 Polyklonal Antikörper für WB, IP, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IP, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 16035-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using SERPINB2 Polyclonal antibody (16035-1-AP)

    WB analysis using 16035-1-AP (same clone as 16035-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 16035-1-AP (SERPINB2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16035-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of Jurkat cells using SERPINB2 Polyclonal antibody (16035-1-AP)

    IP experiment of Jurkat using 16035-1-AP (same clone as 16035-1-PBS)

    IP result of anti-SERPINB2 (IP:16035-1-AP, 4ug; Detection:16035-1-AP 1:300) with Jurkat cells lysate 3600ug. This data was developed using the same antibody clone with 16035-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

16035-1-PBS bindet in WB, IP, Indirect ELISA SERPINB2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SERPINB2 fusion protein Ag8906
Vollständiger Name serpin peptidase inhibitor, clade B (ovalbumin), member 2
Berechnetes Molekulargewicht 415 aa, 47 kDa
Beobachtetes Molekulargewicht 45-47 kDa
GenBank-ZugangsnummerBC012609
Gene symbol SERPINB2
Gene ID (NCBI) 5055
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SerpinB2, a plasminogen activator inhibitor-2 (PAI-2), is a serine protease inhibitor of the serpin superfamily that inactivates tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) (PMID: 7506655). SerpinB2 may have both pro-tumor and anti-tumor effects. High expression of tumor cell-associated SerpinB2 facilitates breast cancer cell survival and metastasis (PMID: 24581498; PMID: 28427146), while SerpinB2 expression by breast cancer cells significantly inhibits metastasis by inhibiting extracellular uPA (PMID: 24644264; PMID: 28346421).