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SF3B14 Polyklonaler Antikörper

SF3B14 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 12379-1-PBS

Synonyme

Filter:
  • Western Blot (WB) analysis of various lysates using SF3B14 Polyclonal antibody (12379-1-AP)

    WB analysis using 12379-1-AP (same clone as 12379-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 12379-1-AP (SF3B14 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12379-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

12379-1-PBS bindet in WB, Indirect ELISA SF3B14 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SF3B14 fusion protein Ag3045
Vollständiger Name splicing factor 3B, 14 kDa subunit
Berechnetes Molekulargewicht 14 kDa
Beobachtetes Molekulargewicht 14 kDa
GenBank-ZugangsnummerBC015463
Gene symbol SF3B14
Gene ID (NCBI) 51639
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Pre-mRNA splicing by the human spliceosome requires the sequential recognition by RNA and protein factors of the 5′ and 3′ splice sites,the branch region and the polypyrimidine tract. This sequence is characterized by the stepwise association of the U1, U2, and U4/U5/U6 snRNP particles [PMID:9476892]. Human p14 (SF3b14), a component of the spliceosomal U2 snRNP, interacts directly with the pre-mRNA branch adenosine within the context of the bulged duplex formed between the pre-mRNA branch region and U2 snRNA. This association occurs early in spliceosome assembly and persists within the fully assembled spliceosome [PMID:21062891].