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SFMBT1 Polyklonaler Antikörper

SFMBT1 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 23631-1-PBS

Synonyme

RU1, SFMBT, SFMBT 1

Filter:
  • Western Blot (WB) analysis of various lysates using SFMBT1 Polyclonal antibody (23631-1-AP)

    WB analysis using 23631-1-AP (same clone as 23631-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 23631-1-AP (SFMBT1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23631-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

23631-1-PBS bindet in WB, Indirect ELISA SFMBT1 und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SFMBT1 fusion protein Ag20417
Vollständiger Name Scm-like with four mbt domains 1
Berechnetes Molekulargewicht 866 aa, 98 kDa
Beobachtetes Molekulargewicht 93-98 kDa
GenBank-ZugangsnummerBC014614
Gene symbol SFMBT1
Gene ID (NCBI) 51460
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-affinitätsgereinigt
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Scm-like with four MBT domains protein 1 (SFMBT1) is also named as Renal ubiquitous protein 1 (RU1). SFMBT1 is a transcriptional repressor that associates with chromatin and interacts with the N-terminal tail of histone H3 (PMID: 17599839). SFMBT1 forms a complex with Lys-specific demethylase 1 (LSD1) and they are believed to act together in combination with RNA polymerase II in the transcriptional regulation of histone genes (PMID: 23592795). SFMBT1 is up-regulated in CRC tumor tissues and cells and may be associated with drug resistance (PMID: 35577773). SFMBT1 regulates the expression and interacts with key genes involved in heart muscle and artery development (PWWP2A, as well as myogenic differentiation (MYOD, SIX2) (PMID: 35483874). Testes, endocrine glands, and blood are tissues that highly express SFMBT1 (PMID: 25613900). SFMBT1 is also highly expressed in skeletal muscles specifically in undifferentiated myoblasts, and this expression starts diminishing during muscle differentiation (PMID: 23349461).