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SHH Rekombinanter Antikörper

SHH Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

250549A9

Kat-Nr. : 86106-1-PBS

Synonyme

EC:3.1.-.-, HHG 1, HHG1, HHG-1, HLP3

Filter:
  • Western Blot (WB) analysis of mouse liver tissue using SHH Recombinant antibody (86106-1-RR)

    WB analysis of mouse liver using 86106-1-RR (same clone as 86106-1-PBS)

    mouse liver tissue were subjected to SDS PAGE followed by western blot with 86106-1-RR (SHH antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86106-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of rat liver tissue using SHH Recombinant antibody (86106-1-RR)

    WB analysis of rat liver using 86106-1-RR (same clone as 86106-1-PBS)

    rat liver tissue were subjected to SDS PAGE followed by western blot with 86106-1-RR (SHH antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86106-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

86106-1-PBS bindet in WB, Indirect ELISA SHH und zeigt Reaktivität mit human, Maus, Ratten

Getestete Reaktivität human, Maus, Ratte
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen SHH fusion protein Eg4010
Vollständiger Name sonic hedgehog homolog (Drosophila)
Berechnetes Molekulargewicht 50 kDa
Beobachtetes Molekulargewicht50-60 kDa
GenBank-ZugangsnummerNM_000193
Gene symbol SHH
Gene ID (NCBI) 6469
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SHH, also named as HHG-1, belongs to the hedgehog family. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. It regulates another target, the gli oncogene. The Shh protein is synthesized as a 45-kDa precursor that undergoes an autocatalytic processing event that produces a 19-kDa N-terminal product, responsible for all signaling activities, and a 25-kDa C-terminal fragment (PMID:10753901, PMID: 16282375). SHH can be detected precursor protein as 48-51-kDa polypeptides (PMID: 15292211).