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SHLD3 Polyklonaler Antikörper

SHLD3 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 30735-1-PBS

Synonyme

FLJ26957, REV7-interacting novel NHEJ regulator 1, RINN1, Shield complex subunit 3, Shieldin complex subunit 3

Filter:
  • Western Blot (WB) analysis of various lysates using SHLD3 Polyclonal antibody (30735-1-AP)

    WB analysis using 30735-1-AP (same clone as 30735-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30735-1-AP (SHLD3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30735-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

30735-1-PBS bindet in WB, Indirect ELISA SHLD3 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SHLD3 fusion protein Ag32940
Vollständiger Name SHLD3
Berechnetes Molekulargewicht29 kDa
Beobachtetes Molekulargewicht28-70 kDa
Gene symbol SHLD3
Gene ID (NCBI) 112441434
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SHLD3 (shieldin complex subunit 3), also known as RINN1 or CTC-534A2.2. It is located in Chromosome and expressed in monocyte. The gene is a component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). It has been found that the proper function of MAD2L2 in shieldin requires its dimerization, and the interaction between MAD2L2 and SHLD3 is mediated and accelerated by SHLD2. The dimerization defect MAD2L2 damages the assembly of shieldin and cannot promote the NHEJ. In addition, the dimerization of MAD2L2 and the existence of SHLD3 allow shieldin to interact with TRIP13 ATPase (PMID: 34521823). The calculated molecular weight of SHLD3 is 28 kDa, the antibody can recognize the 70kDa band, which may be related to the interaction between MAD2L2 and SHLD3 as a dimer in shieldin complex.