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SHOC2/Sur-8 Rekombinanter Antikörper

SHOC2/Sur-8 Rekombinant Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

242343E6

Kat-Nr. : 84917-5-PBS

Synonyme

SHOC2, sur-8, KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc 2 homolog

Filter:
  • Western Blot (WB) analysis of various lysates using SHOC2/Sur-8 Recombinant antibody (84917-5-RR)

    WB analysis using 84917-5-RR (same clone as 84917-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84917-5-RR (SHOC2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84917-5-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

84917-5-PBS bindet in WB, Indirect ELISA SHOC2/Sur-8 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen SHOC2/Sur-8 fusion protein Ag11754
Vollständiger Name soc-2 suppressor of clear homolog (C. elegans)
Berechnetes Molekulargewicht 582 aa, 65 kDa
Beobachtetes Molekulargewicht 65 kDa
GenBank-ZugangsnummerBC050445
Gene symbol SHOC2/Sur-8
Gene ID (NCBI) 8036
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SHOC2 is also named as Sur-8. The SHOC2 protein, along with MRAS and PP1C, forms a high affinity, heterotrimeric holoenzyme that activates RAF kinases by dephosphorylating a specific phosphoserine (PMID: 37074066). SHOC2, a key protein mediating the Ras-Raf-ERK pathway, could act as a scaffolding protein to facilitate the activation of the pathway by mediating the interaction of key components of the pathway (PMID: 37170083). The scaffold protein Shoc2 is a critical modulator of ERK1/2 signals, and mutations in the shoc2 gene lead to the human developmental disease known as Noonan-like syndrome with loose anagen hair (NSLH) (PMID: 36265687).