SIRT6 Monoklonaler Antikörper

• Featured Product
• KD/KO Validated

SIRT6 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2H4G8

Kat-Nr. : 67510-1-PBS

Synonyme

2H4G8, EC:2.3.1.-, EC:2.3.1.286, EC:2.4.2.-, hSIRT6

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  WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67510-1-Ig (SIRT6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

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  WB analysis of Jurkat using 67510-1-Ig (same clone as 67510-1-PBS)

  WB result of SIRT6 antibody (67510-1-Ig; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SIRT6 transfected Jurkat cells. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

67510-1-PBS bindet in WB, Indirect ELISA SIRT6 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: SIRT6 fusion protein Ag24103
• Vollständiger Name: sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
• Berechnetes Molekulargewicht: 39 kDa
• Beobachtetes Molekulargewicht: 40 kDa
• GenBank-Zugangsnummer: BC028220
• Gene symbol: SIRT6
• Gene ID (NCBI): 51548
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889).