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SKA2 Polyklonaler Antikörper

SKA2 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 33333-1-PBS

Synonyme

FAM33A, Protein FAM33A, Spindle and kinetochore-associated protein 2

Filter:
  • Western Blot (WB) analysis of various lysates using SKA2 Polyclonal antibody (33333-1-AP)

    WB analysis using 33333-1-AP (same clone as 33333-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33333-1-AP (SKA2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33333-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

33333-1-PBS bindet in WB, Indirect ELISA SKA2 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SKA2 fusion protein Ag37037
Vollständiger Name family with sequence similarity 33, member A
Berechnetes Molekulargewicht121 aa, 14 kDa
Beobachtetes Molekulargewicht15 kDa
GenBank-ZugangsnummerBC017873
Gene symbol FAM33A
Gene ID (NCBI) 348235
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SKA2 (spindle and KT associated 2), also referred to as FAM33A (family with sequence similarity 33, member A), is a recently identified gene involved in cell cycle regulation, and growing evidence is implicating its roles in tumorigenesis and psychiatric disorders. It has been demonstrated that SKA2, along with its coworkers SKA1 and SKA3, constitutes the SKA complex which plays a critical role in the maintenance of the metaphase plate and/or spindle checkpoint silencing during mitosis. SKA2 is over-expressed both in cancer cell lines and clinical samples including small cell lung cancer and breast cancer, whereas downregulation of SKA2 is associated with depression and suicidal ideation. The expression of SKA2 is regulated by transcription factors including NF-κΒ and CREB, miRNAs as well as DNA methylation (PMID: 30906829).