SLC26A3 Polyklonaler Antikörper

SLC26A3 Polyklonal Antikörper für IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 13165-1-PBS

Synonyme

DRA, Down-regulated in adenoma, CLD, Chloride anion exchanger

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  IHC staining of human colon cancer using 13165-1-AP (same clone as 13165-1-PBS)

  Immunohistochemical analysis of paraffin-embedded colon cancer slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon using 13165-1-AP (same clone as 13165-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon using 13165-1-AP (same clone as 13165-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse testis using 13165-1-AP (same clone as 13165-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse testis using 13165-1-AP (same clone as 13165-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using 13165-1-AP (SLC26A3 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13165-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

13165-1-PBS bindet in IHC, Indirect ELISA SLC26A3 und zeigt Reaktivität mit human, Maus

• Getestete Reaktivität: human, Maus
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: SLC26A3 fusion protein Ag3816
• Vollständiger Name: solute carrier family 26, member 3
• Berechnetes Molekulargewicht: 764 aa, 85 kDa
• Beobachtetes Molekulargewicht: 84 kDa
• GenBank-Zugangsnummer: BC025671
• Gene symbol: SLC26A3
• Gene ID (NCBI): 1811
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SLC26A3 (Chloride anion exchanger), also known as DRA. It is expected to be located in the cytoplasm and cell membranes. It is a transmembrane glycoprotein, which is mainly located in the lower digestive tract mucosa, especially in the apical membrane of columnar epithelium and some goblet cells. The expression level of SLC26A3 in intestine is different along different parts of intestine, and there are also differences on crypt-villus axis. It is mainly expressed in the apical membrane of colon epithelial cells, less in jejunum and ileum, but not in esophagus. It participates in the absorption of electrically neutral NaCl in intestine and works with Na+/H+ exchanger. Cl-/HCO3- exchange mediated by SLC26A3 is very important for maintaining intestinal acid-base balance. In duodenum, the physiological function of SLC26A3 is related to HCO3- secretion, which plays a central role in neutralizing gastric acid (PMID: 32989468). The molecular weight of SLC26A3 is 84 kDa.