SLC39A2 Polyklonaler Antikörper

SLC39A2 Polyklonal Antikörper für WB, IHC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 21287-1-PBS

Synonyme

ZIP-2, ZIP2, hZIP2, Eti-1, Eti 1

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  WB analysis using 21287-1-AP (same clone as 21287-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 21287-1-AP (SLC39A2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21287-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon cancer using 21287-1-AP (same clone as 21287-1-PBS)

  Immunohistochemical analysis of paraffin-embedded Colorectal cancer slide using 21287-1-AP (SLC39A2 antibody) at dilution of 1:100 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21287-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon cancer using 21287-1-AP (same clone as 21287-1-PBS)

  Immunohistochemical analysis of paraffin-embedded Colorectal cancer slide using 21287-1-AP (SLC39A2 antibody) at dilution of 1:100 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21287-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse brain using 21287-1-AP (same clone as 21287-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 21287-1-AP (SLC39A2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21287-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 21287-1-AP (same clone as 21287-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 21287-1-AP (SLC39A2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 21287-1-PBS in a different storage buffer formulation.

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Geprüfte Anwendungen

Produktinformation

21287-1-PBS bindet in WB, IHC, Indirect ELISA SLC39A2 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Kaninchen / IgG
• Klonalität: Polyklonal
• Typ: Antikörper
• Immunogen: SLC39A2 fusion protein Ag15807
• Vollständiger Name: solute carrier family 39 (zinc transporter), member 2
• Berechnetes Molekulargewicht: 309 aa, 33 kDa
• Beobachtetes Molekulargewicht: 33 kDa, 66-70 kDa
• GenBank-Zugangsnummer: BC096723
• Gene symbol: SLC39A2
• Gene ID (NCBI): 29986
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Antigen-Affinitätsreinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SLC39A2 (hZIP2) is a human zinc importer in the ZIP family, which is essential in the maintenance of intracellular zinc homeostasis and is upregulated by zinc depletion. SLC39A2 is highly expressed in prostate epithelial cells and is involved in prostate cancer development. Most SLC39 proteins consist of eight transmembrane domains (TMDs), with extracellular or intravesicular amino and carboxy termini (PMID: 34790705). Zip2 gene knockout exacerbated myocardial I/R injury, whereas Zip2 gene transfer reduced myocardial infarction (PMID: 31095941). The predicted molecular weight of SLC39A2 is 33 kDa, and a band of dimers at 66 kDa can also be detected by this antibody (PMID: 24619115).