SLC7A5 Monoklonaler Antikörper

SLC7A5 Monoklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Maus / IgG2b

Getestete Reaktivität

human

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

2G5H3

Kat-Nr. : 67951-1-PBS

Synonyme

LAT1, 2G5H3, 4F2 LC, 4F2 light chain, 4F2LC

---

• 

  WB analysis using 67951-1-Ig (same clone as 67951-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67951-1-Ig (SLC7A5 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control. This data was developed using the same antibody clone with 67951-1-PBS in a different storage buffer formulation.

---

Geprüfte Anwendungen

Produktinformation

67951-1-PBS bindet in WB, Indirect ELISA SLC7A5 und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• Wirt / Isotyp: Maus / IgG2b
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: SLC7A5 fusion protein Ag20291
• Vollständiger Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
• Berechnetes Molekulargewicht: 507 aa, 55 kDa
• Beobachtetes Molekulargewicht: 35-50 kDa
• GenBank-Zugangsnummer: BC039692
• Gene symbol: SLC7A5
• Gene ID (NCBI): 8140
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS only
• Lagerungsbedingungen: Store at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Large neutral amino acid transporter 1 LAT1(also named as SLC7A5) is a sodium- and pH-independent transporter that supplies essential amino acids (e.g., leucine, phenylalanine) to cells. It plays an important role in the blood-brain barrier (BBB), where it facilitates the transport of thyroid hormones, drugs (e.g., l-DOPA, gabapentin), and metabolites to the brain. In addition, its expression is highly upregulated in various types of human cancers, which are characterized by a high demand for amino acids for growth and proliferation. The LAT1 subunit in humans is a 507 amino acid-long polypeptide with a theoretical molecular mass of 55 kDa. The protein is hydrophobic and is predicted to be constituted by 12 transmembrane segments. The apparent molecular mass of the proteins diminished to approximately 35 - 40 kDa.(PMID: 23912240 ;PMID: 26256001)