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OATP1B1/SLCO1B1 Rekombinanter Antikörper

OATP1B1/SLCO1B1 Rekombinant Antikörper für IF/ICC, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

IF/ICC, Indirect ELISA

Konjugation

Unkonjugiert

CloneNo.

230090F6

Kat-Nr. : 83054-5-PBS

Synonyme

SLCO1B1, LST 1, LST1, OATP 2, OATP C

Filter:
  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using OATP1B1/SLCO1B1 Recombinant antibody (83054-5-RR)

    IF Staining of HepG2 using 83054-5-RR (same clone as 83054-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using SLCO1B1 antibody (83054-5-RR, Clone: 230090F6 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) (SA00013-1). This data was developed using the same antibody clone with 83054-5-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

83054-5-PBS bindet in IF/ICC, Indirect ELISA OATP1B1/SLCO1B1 und zeigt Reaktivität mit human

Getestete Reaktivität human
Wirt / Isotyp Kaninchen / IgG
Klonalität Rekombinant
Typ Antikörper
Immunogen Peptid
Vollständiger Name solute carrier organic anion transporter family, member 1B1
Berechnetes Molekulargewicht 76 kDa
GenBank-ZugangsnummerNM_006446
Gene symbol SLCO1B1
Gene ID (NCBI) 10599
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Protein-A-Reinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

A membrane-bound sodium-independent organic anion transporter protein (OATP1B1), encoded by the SLCO1B1 gene (Solute Carrier Organic Anion Transporter Family Member 1B1), is a critical hepatic uptake transporter that plays a pivotal role in the pharmacokinetics and pharmacodynamics of numerous endogenous compounds and xenobiotics. OATP1B1 is expressed predominantly on the basolateral membrane of hepatocytes, where it mediates active intracellular hepatic transport of various anionic compounds. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.