SMAD4 Monoklonaler Antikörper

SMAD4 Monoklonal Antikörper für ELISA

Wirt / Isotyp

Maus / IgG2a

Getestete Reaktivität

human, Maus, Ratte

Anwendung

WB, IF, ELISA

Konjugation

Unkonjugiert

Publikationen(2)

CloneNo.

3H5H1

Kat-Nr. : 60182-1-Ig

Synonyme

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  IHC staining of human breast cancer using 60182-1-Ig

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 60182-1-Ig(SMAD4 antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human breast cancer using 60182-1-Ig

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 60182-1-Ig(SMAD4 antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human breast cancer using 60182-1-Ig

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 60182-1-Ig(SMAD4 antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human breast cancer using 60182-1-Ig

  Immunohistochemical analysis of paraffin-embedded human breast cancer using 60182-1-Ig(SMAD4 antibody) at dilution of 1:50 (under 40x lens).

• 

  IHC staining of human lung cancer using 60182-1-Ig

  Immunohistochemical analysis of paraffin-embedded human lung cancer using 60182-1-Ig(SMAD4 antibody) at dilution of 1:50 (under 10x lens).

• 

  IHC staining of human lung cancer using 60182-1-Ig

  Immunohistochemical analysis of paraffin-embedded human lung cancer using 60182-1-Ig(SMAD4 antibody) at dilution of 1:50 (under 40x lens).

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Geprüfte Anwendungen

Veröffentlichte Anwendungen

• WB: See 1 publications below
• IF: See 1 publications below

Produktinformation

60182-1-Ig bindet in WB, IF, ELISA SMAD4 und zeigt Reaktivität mit human, Maus, Ratten

• Getestete Reaktivität: human, Maus, Ratte
• In Publikationen genannte Reaktivität: human
• Wirt / Isotyp: Maus / IgG2a
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: SMAD4 fusion protein Ag0299
• Vollständiger Name: SMAD family member 4
• Berechnetes Molekulargewicht: 60 kDa
• Beobachtetes Molekulargewicht: 63 kDa
• GenBank-Zugangsnummer: BC002379
• Gene symbol: SMAD4
• Gene ID (NCBI): 4089
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-A-Reinigung
• Lagerungspuffer: PBS with 0.02% sodium azide and 50% glycerol
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

Mammalian homologs of the Drosophila Mad gene include Smad1, Smad2, Smad3, Smad4 (DPC4), Smad5, Smad6, Smad7 and Smad8. Smad1 and Smad5 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGF and activin-mediated growth modulation. Smad4 has been shown to mediate all of the above activities through interactionwith various Smad family members . Smad6 and Smad7 regulate the response to activin/ TGF signaling by interfering with TGF -mediated phosphorylation of other Smad family members. This antibody is a mouse monoclonal antibody raised against an internal region of human SMAD4.

Publikationen

Species	Application	Title
human	WB	Photochem Photobiol Sci; Downregulation of SMAD4 protects HaCaT cells against UVB-induced damage and oxidative stress through the activation of EMT; Authors - Xiangzhi Li
	IF	Br J Pharmacol; Dual targeting chimeric antigen receptor cells enhance antitumour activity by overcoming T cell exhaustion in pancreatic cancer; Authors - Sun Ruixin