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SMAD6 Polyklonaler Antikörper

SMAD6 Polyklonal Antikörper für WB, Indirect ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human, Maus

Anwendung

WB, Indirect ELISA

Konjugation

Unkonjugiert

Kat-Nr. : 18342-1-PBS

Synonyme

hSMAD6, MADH6, Mothers against DPP homolog 6, SMAD family member 6

Filter:
  • Western Blot (WB) analysis of various lysates using SMAD6 Polyclonal antibody (18342-1-AP)

    WB analysis using 18342-1-AP (same clone as 18342-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18342-1-AP (SMAD6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18342-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using SMAD6 Polyclonal antibody (18342-1-AP)

    WB analysis using 18342-1-AP (same clone as 18342-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18342-1-AP (SMAD6 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18342-1-PBS in a different storage buffer formulation.

Geprüfte Anwendungen

Produktinformation

18342-1-PBS bindet in WB, Indirect ELISA SMAD6 und zeigt Reaktivität mit human, Maus

Getestete Reaktivität human, Maus
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SMAD6 fusion protein Ag13128
Vollständiger Name SMAD family member 6
Berechnetes Molekulargewicht 53 kDa
Beobachtetes Molekulargewicht52 kDa
GenBank-ZugangsnummerBC012986
Gene symbol SMAD6
Gene ID (NCBI) 4091
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS only
LagerungsbedingungenStore at -80°C. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SMAD6 is an intracellular signal transduction protein that belongs to the SMAD protein family. It acts as a negative regulator in the transforming growth factor-beta (TGF-β) signaling pathway, binding to TGF-β receptors and inhibiting the phosphorylation of SMAD2/SMAD3, thereby blocking the transmission of TGF-β signals. Additionally, SMAD6 is involved in the regulation of the bone morphogenetic protein (BMP) signaling pathway, affecting cell proliferation, differentiation, and apoptosis. During development, SMAD6 is crucial for the formation of bones and cartilage. Its abnormal expression is associated with various diseases, including skeletal developmental abnormalities and certain types of cancer.