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  • KD/KO Validated

SMARCAL1 Polyklonaler Antikörper

SMARCAL1 Polyklonal Antikörper für WB, ELISA

Wirt / Isotyp

Kaninchen / IgG

Getestete Reaktivität

human

Anwendung

WB, IHC, IF, IP, ELISA

Konjugation

Unkonjugiert

Publikationen(4)

Kat-Nr. : 12513-1-AP

Synonyme

Sucrose nonfermenting protein 2-like 1, hHARP, HepA-related protein, HepA related protein, HARP



Geprüfte Anwendungen

Erfolgreiche Detektion in WBHEK-293-Zellen, Jurkat-Zellen

Empfohlene Verdünnung

AnwendungVerdünnung
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Produktinformation

12513-1-AP bindet in WB, IHC, IF, IP, ELISA SMARCAL1 und zeigt Reaktivität mit human

Getestete Reaktivität human
In Publikationen genannte Reaktivitäthuman
Wirt / Isotyp Kaninchen / IgG
Klonalität Polyklonal
Typ Antikörper
Immunogen SMARCAL1 fusion protein Ag3194
Vollständiger Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
Berechnetes Molekulargewicht 954 aa, 106 kDa
Beobachtetes Molekulargewicht 106 kDa
GenBank-ZugangsnummerBC016482
Gene symbol SMARCAL1
Gene ID (NCBI) 50485
Konjugation Unkonjugiert
Form Liquid
Reinigungsmethode Antigen-Affinitätsreinigung
Lagerungspuffer PBS with 0.02% sodium azide and 50% glycerol
LagerungsbedingungenBei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

SMARCAL1 is identified as a factor that favors tumor immune evasion by a dual mechanism involving both the suppression of innate immune signaling and the induction of PD-L1-mediated immune checkpoint responses. Mechanistically, SMARCAL1 limits endogenous DNA damage, thereby suppressing cGAS-STING-dependent signaling during cancer cell growth. Simultaneously, it cooperates with the AP-1 family member JUN to maintain chromatin accessibility at a PD-L1 transcriptional regulatory element, thereby promoting PD-L1 expression in cancer cells (PMID: 38301646).

Protokolle

PRODUKTSPEZIFISCHE PROTOKOLLE
WB protocol for SMARCAL1 antibody 12513-1-APProtokoll herunterladen
STANDARD-PROTOKOLLE
Klicken Sie hier, um unsere Standardprotokolle anzuzeigen

Publikationen

SpeciesApplicationTitle
humanWB,IP

Sci Total Environ

LncRNA MT1DP promotes cadmium-induced DNA replication stress by inhibiting chromatin recruitment of SMARCAL1.

Authors - Wenya Feng
humanWB

J Exp Clin Cancer Res

RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma

Authors - Qiu Tu
  • KD Validated
humanWB,IHC,IF

Cancer Lett

Oncogenic functions and therapeutic potentials of targeted inhibition of SMARCAL1 in small cell lung cancer

Authors - Bei-Bei Sun
humanWB,IHC,IF

Sci Rep

Pan-cancer analysis reveals SMARCAL1 expression is associated with immune cell infiltration and poor prognosis in various cancers

Authors - Wu-Jie Zhao
  • KD Validated

Rezensionen

The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.


FH

imene (Verified Customer) (12-05-2024)

This ab is very suitable for WB, diluted to the 1:500 in 5% Milk TBST sollution. the sollution can be reused at least 5 times if stored correctly.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:500
  • Cell Tissue Type: Breast Cancer cell line